Spheroids of cardiomyocytes derived from human-induced pluripotent stem cells improve recovery from myocardial injury in mice

The microenvironment of native heart tissue may be better replicated when cardiomyocytes are cultured in three-dimensional clusters (i.e., spheroids) than in monolayers or as individual cells. Thus, we differentiated human cardiac lineage-induced pluripotent stem cells in cardiomyocytes (hiPSC-CMs)...

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Veröffentlicht in:Am J Physiol Heart Circ Physiol
Hauptverfasser: Mattapally, Saidulu, Zhu, Wuqiang, Fast, Vladimir G., Gao, Ling, Worley, Chelsea, Kannappan, Ramaswamy, Borovjagin, Anton V., Zhang, Jianyi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139622/
https://ncbi.nlm.nih.gov/pubmed/29631371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00688.2017
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