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Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulation

Functional myocardium derived from human induced pluripotent stem cells (hiPSCs) can be impactful for cardiac disease modeling, drug testing, and the repair of injured myocardium. However, when hiPSCs are differentiated into cardiomyocytes, they do not possess characteristics of mature myocytes whic...

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Pubblicato in:PLoS One
Autori principali: LaBarge, Wesley, Mattappally, Saidulu, Kannappan, Ramaswamy, Fast, Vladimir G., Pretorius, Daniëlle, Berry, Joel L., Zhang, Jianyi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611624/
https://ncbi.nlm.nih.gov/pubmed/31276558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219442
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