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Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulation

Functional myocardium derived from human induced pluripotent stem cells (hiPSCs) can be impactful for cardiac disease modeling, drug testing, and the repair of injured myocardium. However, when hiPSCs are differentiated into cardiomyocytes, they do not possess characteristics of mature myocytes whic...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: LaBarge, Wesley, Mattappally, Saidulu, Kannappan, Ramaswamy, Fast, Vladimir G., Pretorius, Daniëlle, Berry, Joel L., Zhang, Jianyi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611624/
https://ncbi.nlm.nih.gov/pubmed/31276558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219442
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