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Transactivation domain of p53 regulates DNA repair and integrity in human iPS cells
The role of p53 transactivation domain (p53-TAD), a multifunctional and dynamic domain, on DNA repair and retaining DNA integrity in human induced pluripotent stem cells (hiPSCs) has never been studied. p53-TAD was knocked out in iPSCs using CRISPR/Cas9 and was confirmed by DNA sequencing. p53-TAD k...
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| Опубликовано в: : | Am J Physiol Heart Circ Physiol |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Physiological Society
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6172637/ https://ncbi.nlm.nih.gov/pubmed/29775409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00160.2018 |
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