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A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

The reprogramming of differentiated cells to pluripotent cells (induced pluripotent stem (iPS) cells) is known to be an inefficient process. We recently reported that cells with short telomeres cannot be reprogrammed to iPS cells despite their normal proliferation rates(1, 2), probably reflecting th...

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Библиографические подробности
Главные авторы: Marión, Rosa M., Strati, Katerina, Li, Han, Murga, Matilde, Blanco, Raquel, Ortega, Sagrario, Fernandez-Capetillo, Oscar, Serrano, Manuel, Blasco, Maria A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624089/
https://ncbi.nlm.nih.gov/pubmed/19668189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08287
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