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The Ink4/Arf locus is a barrier for iPS reprogramming
The mechanisms involved in the reprogramming of differentiated cells into induced Pluripotent Stem (iPS) cells by Oct4, Klf4 and Sox2 (3F) remain poorly understood (1). The Ink4/Arf tumour suppressor locus encodes three potent inhibitors of proliferation, namely p16(Ink4a), p15(Ink4b) and Arf, which...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3578184/ https://ncbi.nlm.nih.gov/pubmed/19668188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08290 |
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