The Ink4a/Arf Locus Is a Barrier to Direct Neuronal Transdifferentiation

Non-neurogenic cell types, such as cortical astroglia and fibroblasts, can be directly converted into neurons by the overexpression of defined transcription factors. Normally, the cellular phenotype of such differentiated cells is remarkably stable and resists direct cell transdifferentiation. Here...

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Detalhes bibliográficos
Main Authors: Price, James D., Park, Ki-Youb, Chen, Jiadong, Salinas, Ryan D., Cho, Mathew J., Kriegstein, Arnold R., Lim, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160784/
https://ncbi.nlm.nih.gov/pubmed/25209293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3159-13.2014
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