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SWI/SNF Mediates Polycomb Eviction and Epigenetic Reprogramming of the INK4b-ARF-INK4a Locus

Stable silencing of the INK4b-ARF-INK4a tumor suppressor locus occurs in a variety of human cancers, including malignant rhabdoid tumors (MRTs). MRTs are extremely aggressive cancers caused by the loss of the hSNF5 subunit of the SWI/SNF chromatin-remodeling complex. We found previously that, in MRT...

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Auteurs principaux: Kia, Sima Kheradmand, Gorski, Marcin M., Giannakopoulos, Stavros, Verrijzer, C. Peter
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2008
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423153/
https://ncbi.nlm.nih.gov/pubmed/18332116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02019-07
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