EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescence

BACKGROUND: The INK4b-ARF-INK4a tumour suppressor locus controls the balance between progenitor cell renewal and cancer. In this study, we investigated how higher-order chromatin structure modulates differential expression of the human INK4b-ARF-INK4a locus during progenitor cell differentiation, ce...

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Detalhes bibliográficos
Main Authors: Kheradmand Kia, Sima, Solaimani Kartalaei, Parham, Farahbakhshian, Elnaz, Pourfarzad, Farzin, von Lindern, Marieke, Verrijzer, C Peter
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225837/
https://ncbi.nlm.nih.gov/pubmed/19954516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-2-16
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