DNA damage-free iPS cells exhibit potential to yield competent cardiomyocytes

DNA damage accrued in induced pluripotent stem cell (iPSC)-derived cardiomyocytes during in vitro culture practices lessens their therapeutic potential. We determined whether DNA-damage-free iPSCs (DdF-iPSCs) can be selected using stabilization of p53, a transcription factor that promotes apoptosis...

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Bibliografische gegevens
Gepubliceerd in:Am J Physiol Heart Circ Physiol
Hoofdauteurs: Miller, Jessica M., Mardhekar, Nikhil M., Pretorius, Danielle, Krishnamurthy, Prasanna, Rajasekaran, Namakkal Soorappan, Zhang, Jianyi, Kannappan, Ramaswamy
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7276931/
https://ncbi.nlm.nih.gov/pubmed/32057252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00658.2019
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