Identification, Design and Synthesis of Novel Pyrazolopyridine Influenza Virus Nonstructural Protein 1 Antagonists

Nonstructural protein 1 (NS1) plays a crucial function in the replication, spread, and pathogenesis of influenza virus by inhibiting the host innate immune response. Here we report the discovery and optimization of novel pyrazolopyridine NS1 antagonists that can potently inhibit influenza A/PR/8/34...

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Pubblicato in:Bioorg Med Chem Lett
Autori principali: Patnaik, Samaijit, Basu, Dipanwita, Southall, Noel, Dehdashti, Seameen, Wan, Kanny K., Zheng, Wei, Ferrer, Marc, Taylor, Mercedes, Engel, Daniel A., Marugan, Juan Jose
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8290212/
https://ncbi.nlm.nih.gov/pubmed/30852083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.02.027
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