Identification, Design and Synthesis of Novel Pyrazolopyridine Influenza Virus Nonstructural Protein 1 Antagonists

Nonstructural protein 1 (NS1) plays a crucial function in the replication, spread, and pathogenesis of influenza virus by inhibiting the host innate immune response. Here we report the discovery and optimization of novel pyrazolopyridine NS1 antagonists that can potently inhibit influenza A/PR/8/34...

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Vydáno v:Bioorg Med Chem Lett
Hlavní autoři: Patnaik, Samaijit, Basu, Dipanwita, Southall, Noel, Dehdashti, Seameen, Wan, Kanny K., Zheng, Wei, Ferrer, Marc, Taylor, Mercedes, Engel, Daniel A., Marugan, Juan Jose
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8290212/
https://ncbi.nlm.nih.gov/pubmed/30852083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.02.027
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