Identification, Design and Synthesis of Novel Pyrazolopyridine Influenza Virus Nonstructural Protein 1 Antagonists

Nonstructural protein 1 (NS1) plays a crucial function in the replication, spread, and pathogenesis of influenza virus by inhibiting the host innate immune response. Here we report the discovery and optimization of novel pyrazolopyridine NS1 antagonists that can potently inhibit influenza A/PR/8/34...

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Détails bibliographiques
Publié dans:Bioorg Med Chem Lett
Auteurs principaux: Patnaik, Samaijit, Basu, Dipanwita, Southall, Noel, Dehdashti, Seameen, Wan, Kanny K., Zheng, Wei, Ferrer, Marc, Taylor, Mercedes, Engel, Daniel A., Marugan, Juan Jose
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8290212/
https://ncbi.nlm.nih.gov/pubmed/30852083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.02.027
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