A Novel Brain Penetrant NPS Receptor Antagonist, NCGC00185684, Blocks Alcohol-Induced ERK-Phosphorylation in the Central Amygdala and Decreases Operant Alcohol Self-Administration in Rats

The Neuropeptide S receptor, a Gs/Gq-coupled GPCR expressed in brain regions involved in mediating drug reward, has recently emerged as a candidate therapeutic target in addictive disorders. Here, we describe the in vitro and in vivo pharmacology of a novel, selective and brain penetrant NPSR antago...

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Main Authors: Thorsell, Annika, Tapocik, Jenica D., Liu, Ke, Zook, Michelle, Bell, Lauren, Flanigan, Meghan, Patnaik, Samarjit, Marugan, Juan, Damadzic, Ruslan, Dehdashti, Seameen J., Schwandt, Melanie L., Southall, Noel, Austin, Christopher P., Eskay, Robert, Ciccocioppo, Roberto, Zheng, Wei, Heilig, Markus
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682378/
https://ncbi.nlm.nih.gov/pubmed/23761908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4742-12.2013
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