A Novel Brain Penetrant NPS Receptor Antagonist, NCGC00185684, Blocks Alcohol-Induced ERK-Phosphorylation in the Central Amygdala and Decreases Operant Alcohol Self-Administration in Rats

The Neuropeptide S receptor, a Gs/Gq-coupled GPCR expressed in brain regions involved in mediating drug reward, has recently emerged as a candidate therapeutic target in addictive disorders. Here, we describe the in vitro and in vivo pharmacology of a novel, selective and brain penetrant NPSR antago...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Thorsell, Annika, Tapocik, Jenica D., Liu, Ke, Zook, Michelle, Bell, Lauren, Flanigan, Meghan, Patnaik, Samarjit, Marugan, Juan, Damadzic, Ruslan, Dehdashti, Seameen J., Schwandt, Melanie L., Southall, Noel, Austin, Christopher P., Eskay, Robert, Ciccocioppo, Roberto, Zheng, Wei, Heilig, Markus
التنسيق: Artigo
اللغة:Inglês
منشور في: Society for Neuroscience 2013
الموضوعات:
Articles
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682378/
https://ncbi.nlm.nih.gov/pubmed/23761908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4742-12.2013
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