Binge-Like Ethanol Consumption Increases Corticosterone Levels and Neurodegneration whereas occupancy of Type II Glucocorticoid Receptors with Mifepristone is Neuroprotective

Excessive ethanol (EtOH) use leads to impaired memory and cognition. Using a rat model of binge-like intoxication, we tested whether elevated corticosterone (Cort) levels contribute to the neurotoxic consequences of EtOH exposure. Rats were adrenalectomized (Adx) and implanted with cholesterol pelle...

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Autori principali: Cippitelli, Andrea, Damadzic, Ruslan, Hamelink, Carol, Brunnquell, Michael, Thorsell, Annika, Heilig, Markus, Eskay, Robert L
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561503/
https://ncbi.nlm.nih.gov/pubmed/22500955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1369-1600.2012.00451.x
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