Structure Activity Relationship of Imidazo-pyridinium Analogs as Antagonists of Neuropeptide S Receptor

The discovery and characterization of a novel chemical series of phosphorothioyl-containing imidazopyridines as potent Neuropeptide S Receptor antagonists is presented. The synthesis of analogs and their SAR with respect to the Gq, Gs, and ERK pathways is detailed. Pharmacokinetics and in vivo effic...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Patnaik, Samarjit, Marugan, Juan J., Liu, Ke, Zheng, Wei, Southall, Noel, Dehdashti, Seameen J., Thorsell, Annika, Heilig, Markus, Bell, Lauren, Zook, Michelle, Eskay, Bob, Brimacombe, Kyle R., Austin, Christopher P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877059/
https://ncbi.nlm.nih.gov/pubmed/24171469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400904m
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