Tacr1 Gene Variation and Neurokinin 1 Receptor Expression Is Associated with Antagonist Efficacy in Genetically Selected Alcohol-Preferring Rats

BACKGROUND: Genetic deletion or antagonism of the neurokinin 1 receptor (NK1R) decreases alcohol intake, alcohol reward, and stress-induced alcohol relapse in rodents, while TACR1 variation is associated with alcoholism in humans. METHODS: We used L822429, a specific antagonist with high affinity fo...

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Auteurs principaux: Schank, Jesse R., Tapocik, Jenica D., Barbier, Estelle, Damadzic, Ruslan, Eskay, Robert L., Sun, Hui, Rowe, Kelly E., King, Courtney E., Yao, Mengdi, Flanigan, Meghan E., Solomon, Matthew G., Karlsson, Camilla, Cheng, Kejun, Rice, Kenner C., Heilig, Markus
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773538/
https://ncbi.nlm.nih.gov/pubmed/23419547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2012.12.027
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