PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair

Polo-like kinase 1 (PLK1) is a master kinase that regulates cell cycle progression. How its enzymatic activity is regulated in response to DNA damage is not fully understood. We show that PLK1 is enriched at double strand breaks (DSBs) within seconds of UV laser irradiation in a PARP-1-dependent man...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Peng, Bin, Shi, Ruifeng, Bian, Jing, Li, Yuwei, Wang, Peipei, Wang, Hailong, Liao, Ji, Zhu, Wei-Guo, Xu, Xingzhi
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287952/
https://ncbi.nlm.nih.gov/pubmed/34197606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab584
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