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PARP1 suppresses homologous recombination events in mice in vivo

Recent studies suggest that PARP1 inhibitors, several of which are currently in clinical trial, may selectively kill BRCA1/2 mutant cancers cells. It is thought that the success of this therapy is based on immitigable lethal DNA damage in the cancer cells resultant from the concurrent loss or inhibi...

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Podrobná bibliografie
Hlavní autoři: Claybon, Alison, Karia, Bijal, Bruce, Crystal, Bishop, Alexander J. R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995050/
https://ncbi.nlm.nih.gov/pubmed/20660013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq624
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