PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways

The repair of toxic double-strand breaks (DSB) is critical for the maintenance of genome integrity. The major mechanisms that cope with DSB are: homologous recombination (HR) and classical or alternative nonhomologous end joining (C-NHEJ versus A-EJ). Because these pathways compete for the repair of...

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Autores principales: Beck, Carole, Boehler, Christian, Guirouilh Barbat, Josée, Bonnet, Marie-Elise, Illuzzi, Giuditta, Ronde, Philippe, Gauthier, Laurent R., Magroun, Najat, Rajendran, Anbazhagan, Lopez, Bernard S., Scully, Ralph, Boussin, François D., Schreiber, Valérie, Dantzer, Françoise
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027158/
https://ncbi.nlm.nih.gov/pubmed/24598253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku174
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