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Tumor-draining lymph nodes are survival niches that support T cell priming against lymphatic transported tumor antigen and effects of immune checkpoint blockade in TNBC

Triple negative breast cancer (TNBC) is a significant clinical problem to which immunotherapeutic strategies have been applied with limited success. Using the syngeneic E0771 TNBC mouse model, this work explores the potential for antitumor CD8(+) T cell immunity to be primed extratumorally in lympho...

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Bibliografiske detaljer
Udgivet i:Cancer Immunol Immunother
Main Authors: O’Melia, Meghan J., Manspeaker, Margaret P., Thomas, Susan N.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286278/
https://ncbi.nlm.nih.gov/pubmed/33459842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-020-02792-5
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