Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy

PD-1/PD-L1 checkpoint therapy for cancer is commonly considered to act by reactivating T cells in the tumor microenvironment. Here, we present data from 2 mouse tumor models demonstrating an essential involvement of tumor-draining lymph nodes in PD-1 and PD-L1 therapeutic efficacy. Immune activation...

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Publicado en:JCI Insight
Autores principales: Fransen, Marieke F., Schoonderwoerd, Mark, Knopf, Philipp, Camps, Marcel G.M., Hawinkels, Lukas J.A.C., Kneilling, Manfred, van Hall, Thorbald, Ossendorp, Ferry
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328025/
https://ncbi.nlm.nih.gov/pubmed/30518694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124507
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