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Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models

Antibodies blocking the programmed death-ligand 1 (PD-L1) have shown impressive and durable responses in clinical studies. However, this type of immunotherapy is only effective in a subset of patients and not sufficient for rejection of all tumor types. In this study, we explored in two mouse tumor...

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Publicado en:Cells
Main Authors: Sow, Heng Sheng, Ren, Jiang, Camps, Marcel, Ossendorp, Ferry, ten Dijke, Peter
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6523576/
https://ncbi.nlm.nih.gov/pubmed/30959852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8040320
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