Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics

Cancer cells have differential metabolic dependencies compared to their non-malignant counterparts. However, few metabolism-targeting compounds have been successful in clinical trials. Here, we investigated the metabolic vulnerabilities of triple-negative breast cancer (TNBC), in particular those me...

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Vydáno v:Sci Signal
Hlavní autoři: Daniels, Veerle W., Zoeller, Jason J., van Gastel, Nick, McQueeney, Kelley E., Parvin, Salma, Potter, Danielle S., Fell, Geoffrey G., Ferreira, Vinícius G., Yilma, Binyam, Gupta, Rajat, Spetz, Johan, Bhola, Patrick D., Endress, Jennifer E., Harris, Isaac S., Carrilho, Emanuel, Sarosiek, Kristopher A., Scadden, David T., Brugge, Joan S., Letai, Anthony
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285073/
https://ncbi.nlm.nih.gov/pubmed/34103421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.abc7405
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