Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics

Cancer cells have differential metabolic dependencies compared to their non-malignant counterparts. However, few metabolism-targeting compounds have been successful in clinical trials. Here, we investigated the metabolic vulnerabilities of triple-negative breast cancer (TNBC), in particular those me...

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Pubblicato in:Sci Signal
Autori principali: Daniels, Veerle W., Zoeller, Jason J., van Gastel, Nick, McQueeney, Kelley E., Parvin, Salma, Potter, Danielle S., Fell, Geoffrey G., Ferreira, Vinícius G., Yilma, Binyam, Gupta, Rajat, Spetz, Johan, Bhola, Patrick D., Endress, Jennifer E., Harris, Isaac S., Carrilho, Emanuel, Sarosiek, Kristopher A., Scadden, David T., Brugge, Joan S., Letai, Anthony
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285073/
https://ncbi.nlm.nih.gov/pubmed/34103421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.abc7405
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