Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics

Cancer cells have differential metabolic dependencies compared to their non-malignant counterparts. However, few metabolism-targeting compounds have been successful in clinical trials. Here, we investigated the metabolic vulnerabilities of triple-negative breast cancer (TNBC), in particular those me...

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Udgivet i:Sci Signal
Main Authors: Daniels, Veerle W., Zoeller, Jason J., van Gastel, Nick, McQueeney, Kelley E., Parvin, Salma, Potter, Danielle S., Fell, Geoffrey G., Ferreira, Vinícius G., Yilma, Binyam, Gupta, Rajat, Spetz, Johan, Bhola, Patrick D., Endress, Jennifer E., Harris, Isaac S., Carrilho, Emanuel, Sarosiek, Kristopher A., Scadden, David T., Brugge, Joan S., Letai, Anthony
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285073/
https://ncbi.nlm.nih.gov/pubmed/34103421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.abc7405
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