Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models

Increasing clinical evidence has demonstrated that the deletion or mutation of tumor suppressor genes such as the gene-encoding phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in cancer cells may correlate with an immunosuppressive tumor microenvironment (TME) and poor response or res...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Lin, Yao-Xin, Wang, Yi, Ding, Jianxun, Jiang, Aiping, Wang, Jie, Yu, Mian, Blake, Sara, Liu, Shuaishuai, Bieberich, Charles J., Farokhzad, Omid C., Mei, Lin, Wang, Hao, Shi, Jinjun
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284983/
https://ncbi.nlm.nih.gov/pubmed/34162754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aba9772
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