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Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice

Synthetic mRNA represents an exciting cancer vaccine technology for the implementation of effective cancer immunotherapy. However, inefficient in vivo mRNA delivery along with a requirement for immune co-stimulation present major hurdles to achieving anti-tumor therapeutic efficacy. Here, we demonst...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biomaterials
Hauptverfasser: Islam, Mohammad Ariful, Rice, Jamie, Reesor, Emma, Zope, Harshal, Tao, Wei, Lim, Michael, Ding, Jianxun, Chen, Yunhan, Aduluso, Dike, Zetter, Bruce R., Farokhzad, Omid C., Shi, Jinjun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Ltd. 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7528902/
https://ncbi.nlm.nih.gov/pubmed/33099060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2020.120431
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