Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

PTEN is a well-characterized tumour-suppressor gene that is lost or mutated in about half of metastatic castration-resistant prostate cancers and in many other human cancers. The restoration of functional PTEN as a treatment for prostate cancer has however proven difficult. Here, we show that PTEN m...

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Detalhes bibliográficos
Publicado no:Nat Biomed Eng
Main Authors: Islam, Mohammad Ariful, Xu, Yingjie, Tao, Wei, Ubellacker, Jessalyn M., Lim, Michael, Aum, Daniel, Lee, Gha Young, Zhou, Kun, Zope, Harshal, Yu, Mikyung, Cao, Wuji, Oswald, James Trevor, Dinarvand, Meshkat, Mahmoudi, Morteza, Langer, Robert, Kantoff, Philip W., Farokhzad, Omid C., Zetter, Bruce R., Shi, Jinjun
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486184/
https://ncbi.nlm.nih.gov/pubmed/31015614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-018-0284-0
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