Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

PTEN is a well-characterized tumour-suppressor gene that is lost or mutated in about half of metastatic castration-resistant prostate cancers and in many other human cancers. The restoration of functional PTEN as a treatment for prostate cancer has however proven difficult. Here, we show that PTEN m...

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Vydáno v:Nat Biomed Eng
Hlavní autoři: Islam, Mohammad Ariful, Xu, Yingjie, Tao, Wei, Ubellacker, Jessalyn M., Lim, Michael, Aum, Daniel, Lee, Gha Young, Zhou, Kun, Zope, Harshal, Yu, Mikyung, Cao, Wuji, Oswald, James Trevor, Dinarvand, Meshkat, Mahmoudi, Morteza, Langer, Robert, Kantoff, Philip W., Farokhzad, Omid C., Zetter, Bruce R., Shi, Jinjun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486184/
https://ncbi.nlm.nih.gov/pubmed/31015614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-018-0284-0
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