Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy

Biodegradable polymeric nanoparticles (NPs) have demonstrated significant potential to improve the systemic delivery of RNA interference (RNAi) therapeutics, such as small interfering RNA (siRNA), for cancer therapy. However, the slow and inefficient siRNA release inside tumor cells generally observ...

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Bibliografiske detaljer
Udgivet i:Small
Main Authors: Xu, Xiaoding, Wu, Jun, Liu, Shuaishuai, Saw, Phei Er, Tao, Wei, Li, Yujing, Krygsman, Lisa, Yegnasubramanian, Srinivasan, De Marzo, Angelo M., Shi, Jinjun, Bieberich, Charles J., Farokhzad, Omid C.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286670/
https://ncbi.nlm.nih.gov/pubmed/30230235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/smll.201802565
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