Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition

Loss of function in tumor suppressor genes is commonly associated with the onset/progression of cancer and treatment resistance. The p53 tumor suppressor gene, a master regulator of diverse cellular pathways, is frequently altered in various cancers, for example, in ~36% of hepatocellular carcinomas...

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Vydáno v:Sci Transl Med
Hlavní autoři: Kong, Na, Tao, Wei, Ling, Xiang, Wang, Junqing, Xiao, Yuling, Shi, Sanjun, Ji, Xiaoyuan, Shajii, Aram, Gan, Silvia Tian, Kim, Na Yoon, Duda, Dan G., Xie, Tian, Farokhzad, Omid C., Shi, Jinjun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7024563/
https://ncbi.nlm.nih.gov/pubmed/31852795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaw1565
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