Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy

Simian immunodeficiency virus (SIV) challenge of rhesus macaques (RMs) vaccinated with strain 68–1 Rhesus Cytomegalovirus (RhCMV) vectors expressing SIV proteins (RhCMV/SIV) results in a binary outcome: stringent control and subsequent clearance of highly pathogenic SIV in ~55% of vaccinated RMs wit...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Barrenäs, Fredrik, Hansen, Scott G., Law, Lynn, Driscoll, Connor, Green, Richard R., Smith, Elise, Chang, Jean, Golez, Inah, Urion, Taryn, Peng, Xinxia, Whitmore, Leanne, Newhouse, Daniel, Hughes, Colette M., Morrow, David, Randall, Kurt T., Selseth, Andrea N., Ford, Julia C., Gilbride, Roxanne M., Randall, Bryan E., Ainslie, Emily, Oswald, Kelli, Shoemaker, Rebecca, Fast, Randy, Bosche, William J., Axthelm, Michael K., Fukazawa, Yoshinori, Pavlakis, George N., Felber, Barbara K., Fourati, Slim, Sekaly, Rafick-Pierre, Lifson, Jeffrey D., Komorowski, Jan, Kosmider, Ewelina, Shao, Danica, Song, Wenjun, Edlefsen, Paul T., Picker, Louis J., Gale, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284654/
https://ncbi.nlm.nih.gov/pubmed/34228762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009278
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