A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge

Previous studies have established that strain 68–1-derived Rhesus cytomegalovirus (RhCMV) vectors expressing simian immune deficiency virus (SIV) proteins (RhCMV/SIV) are able to elicit and maintain cellular immune responses that provide protection against mucosal challenge with highly pathogenic SI...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Hansen, Scott G., Marshall, Emily E., Malouli, Daniel, Ventura, Abigail B., Hughes, Colette M., Ainslie, Emily, Ford, Julia C., Morrow, David, Gilbride, Roxanne M., Bae, Jin Y., Legasse, Alfred W., Oswald, Kelli, Shoemaker, Rebecca, Berkemeier, Brian, Bosche, William J., Hull, Michael, Womack, Jennie, Shao, Jason, Edlefsen, Paul T., Reed, Jason S., Burwitz, Ben J., Sacha, Jonah B., Axthelm, Michael K., Früh, Klaus, Lifson, Jeffrey D., Picker, Louis J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788755/
https://ncbi.nlm.nih.gov/pubmed/31316007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaw2607
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