A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge

Previous studies have established that strain 68–1-derived Rhesus cytomegalovirus (RhCMV) vectors expressing simian immune deficiency virus (SIV) proteins (RhCMV/SIV) are able to elicit and maintain cellular immune responses that provide protection against mucosal challenge with highly pathogenic SI...

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Publicado en:Sci Transl Med
Autores principales: Hansen, Scott G., Marshall, Emily E., Malouli, Daniel, Ventura, Abigail B., Hughes, Colette M., Ainslie, Emily, Ford, Julia C., Morrow, David, Gilbride, Roxanne M., Bae, Jin Y., Legasse, Alfred W., Oswald, Kelli, Shoemaker, Rebecca, Berkemeier, Brian, Bosche, William J., Hull, Michael, Womack, Jennie, Shao, Jason, Edlefsen, Paul T., Reed, Jason S., Burwitz, Ben J., Sacha, Jonah B., Axthelm, Michael K., Früh, Klaus, Lifson, Jeffrey D., Picker, Louis J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788755/
https://ncbi.nlm.nih.gov/pubmed/31316007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaw2607
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