A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge

Previous studies have established that strain 68–1-derived Rhesus cytomegalovirus (RhCMV) vectors expressing simian immune deficiency virus (SIV) proteins (RhCMV/SIV) are able to elicit and maintain cellular immune responses that provide protection against mucosal challenge with highly pathogenic SI...

Full description

Saved in:
Bibliographic Details
Published in:Sci Transl Med
Main Authors: Hansen, Scott G., Marshall, Emily E., Malouli, Daniel, Ventura, Abigail B., Hughes, Colette M., Ainslie, Emily, Ford, Julia C., Morrow, David, Gilbride, Roxanne M., Bae, Jin Y., Legasse, Alfred W., Oswald, Kelli, Shoemaker, Rebecca, Berkemeier, Brian, Bosche, William J., Hull, Michael, Womack, Jennie, Shao, Jason, Edlefsen, Paul T., Reed, Jason S., Burwitz, Ben J., Sacha, Jonah B., Axthelm, Michael K., Früh, Klaus, Lifson, Jeffrey D., Picker, Louis J.
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788755/
https://ncbi.nlm.nih.gov/pubmed/31316007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaw2607
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items