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Nodosome Inhibition as a Novel Broad-Spectrum Antiviral Strategy against Arboviruses, Enteroviruses, and SARS-CoV-2

In the present report, we describe two small molecules with broad-spectrum antiviral activity. These drugs block the formation of the nodosome. The studies were prompted by the observation that infection of human fetal brain cells with Zika virus (ZIKV) induces the expression of nucleotide-binding o...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Limonta, Daniel, Dyna-Dagman, Lovely, Branton, William, Mancinelli, Valeria, Makio, Tadashi, Wozniak, Richard W., Power, Christopher, Hobman, Tom C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284462/
https://ncbi.nlm.nih.gov/pubmed/34001511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00491-21
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