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Nodosome Inhibition as a Novel Broad-Spectrum Antiviral Strategy against Arboviruses, Enteroviruses, and SARS-CoV-2

In the present report, we describe two small molecules with broad-spectrum antiviral activity. These drugs block the formation of the nodosome. The studies were prompted by the observation that infection of human fetal brain cells with Zika virus (ZIKV) induces the expression of nucleotide-binding o...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Limonta, Daniel, Dyna-Dagman, Lovely, Branton, William, Mancinelli, Valeria, Makio, Tadashi, Wozniak, Richard W., Power, Christopher, Hobman, Tom C.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284462/
https://ncbi.nlm.nih.gov/pubmed/34001511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00491-21
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