Nodosome Inhibition as a Novel Broad-Spectrum Antiviral Strategy against Arboviruses, Enteroviruses, and SARS-CoV-2

In the present report, we describe two small molecules with broad-spectrum antiviral activity. These drugs block the formation of the nodosome. The studies were prompted by the observation that infection of human fetal brain cells with Zika virus (ZIKV) induces the expression of nucleotide-binding o...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Limonta, Daniel, Dyna-Dagman, Lovely, Branton, William, Mancinelli, Valeria, Makio, Tadashi, Wozniak, Richard W., Power, Christopher, Hobman, Tom C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2021
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284462/
https://ncbi.nlm.nih.gov/pubmed/34001511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00491-21
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