Scap Structures Highlight Key Role for Rotation of Intertwined Luminal Loops in Cholesterol Sensing

The cholesterol-sensing protein Scap induces cholesterol synthesis by transporting membrane-bound transcription factors called SREBPs from ER to Golgi for proteolytic activation. Transport requires interaction between Scap’s two ER luminal loops (L1 and L7) that flank an intramembrane sterol-sensing...

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Publicat a:Cell
Autors principals: Kober, Daniel L., Radhakrishnan, Arun, Goldstein, Joseph L., Brown, Michael S., Clark, Lindsay D., Bai, Xiao-chen, Rosenbaum, Daniel M.
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8277531/
https://ncbi.nlm.nih.gov/pubmed/34139175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.05.019
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