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The interplay of Rac1 activity, ubiquitination and GDI binding and its consequences for endothelial cell spreading
Signaling by the Rho GTPase Rac1 is key to the regulation of cytoskeletal dynamics, cell spreading and adhesion. It is widely accepted that the inactive form of Rac1 is bound by Rho GDI, which prevents Rac1 activation and Rac1-effector interactions. In addition, GDI-bound Rac1 is protected from prot...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8274835/ https://ncbi.nlm.nih.gov/pubmed/34252134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0254386 |
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