The Cullin-3–Rbx1–KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB

RhoGTPases control endothelial cell (EC) migration, adhesion, and barrier formation. Whereas the relevance of RhoA for endothelial barrier function is widely accepted, the role of the RhoA homologue RhoB is poorly defined. RhoB and RhoA are 85% identical, but RhoB’s subcellular localization and half...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Principais autores: Kovačević, Igor, Sakaue, Tomohisa, Majoleé, Jisca, Pronk, Manon C., Maekawa, Masashi, Geerts, Dirk, Fernandez-Borja, Mar, Higashiyama, Shigeki, Hordijk, Peter L.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839774/
https://ncbi.nlm.nih.gov/pubmed/29358211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201606055
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