The Cullin-3–Rbx1–KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB

RhoGTPases control endothelial cell (EC) migration, adhesion, and barrier formation. Whereas the relevance of RhoA for endothelial barrier function is widely accepted, the role of the RhoA homologue RhoB is poorly defined. RhoB and RhoA are 85% identical, but RhoB’s subcellular localization and half...

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Dettagli Bibliografici
Pubblicato in:J Cell Biol
Autori principali: Kovačević, Igor, Sakaue, Tomohisa, Majoleé, Jisca, Pronk, Manon C., Maekawa, Masashi, Geerts, Dirk, Fernandez-Borja, Mar, Higashiyama, Shigeki, Hordijk, Peter L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2018
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839774/
https://ncbi.nlm.nih.gov/pubmed/29358211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201606055
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