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CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity
RhoGTPases regulate cytoskeletal dynamics, migration and cell-cell adhesion in endothelial cells. Besides regulation at the level of guanine nucleotide binding, they also undergo post-translational modifications, for example ubiquitination. RhoGTPases are ubiquitinated by Cullin RING ligases which a...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6544660/ https://ncbi.nlm.nih.gov/pubmed/31148579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44595-4 |
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