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FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB

Rho GTPases control both the actin cytoskeleton and adherens junction stability and are recognized as essential regulators of endothelial barrier function. They act as molecular switches and are primarily regulated by the exchange of GDP and GTP. However, posttranslational modifications such as phos...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Biol Cell
Egile Nagusiak: Pronk, Manon C. A., Majolée, Jisca, Loregger, Anke, van Bezu, Jan S. M., Zelcer, Noam, Hordijk, Peter L., Kovačević, Igor
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Cell Biology 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589702/
https://ncbi.nlm.nih.gov/pubmed/30601691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-04-0259
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