Cullin‐3/KCTD10 E3 complex is essential for Rac1 activation through RhoB degradation in human epidermal growth factor receptor 2‐positive breast cancer cells

Rho GTPase Rac1 is a central regulator of F‐actin organization and signal transduction to control plasma membrane dynamics and cell proliferation. Dysregulated Rac1 activity is often observed in various cancers including breast cancer and is suggested to be critical for malignancy. Here, we showed t...

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Detalles Bibliográficos
Publicado en:Cancer Sci
Main Authors: Murakami, Akari, Maekawa, Masashi, Kawai, Katsuhisa, Nakayama, Jun, Araki, Nobukazu, Semba, Kentaro, Taguchi, Tomohiko, Kamei, Yoshiaki, Takada, Yasutsugu, Higashiyama, Shigeki
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6361568/
https://ncbi.nlm.nih.gov/pubmed/30515933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13899
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