TRANSFORMER: A Randomized Phase II Study Comparing Bipolar Androgen Therapy Versus Enzalutamide in Asymptomatic Men With Castration-Resistant Metastatic Prostate Cancer

PURPOSE: Prostate cancer (PCa) becomes resistant to androgen ablation through adaptive upregulation of the androgen receptor in response to the low-testosterone microenvironment. Bipolar androgen therapy (BAT), defined as rapid cycling between high and low serum testosterone, disrupts this adaptive...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Oncol
Prif Awduron: Denmeade, Samuel R., Wang, Hao, Agarwal, Neeraj, Smith, David C., Schweizer, Michael T., Stein, Mark N., Assikis, Vasileios, Twardowski, Przemyslaw W., Flaig, Thomas W., Szmulewitz, Russell Z., Holzbeierlein, Jeffrey M., Hauke, Ralph J., Sonpavde, Guru, Garcia, Jorge A., Hussain, Arif, Sartor, Oliver, Mao, Shifeng, Cao, Harry, Fu, Wei, Wang, Ting, Abdallah, Rehab, Lim, Su Jin, Bolejack, Vanessa, Paller, Channing J., Carducci, Michael A., Markowski, Mark C., Eisenberger, Mario A., Antonarakis, Emmanuel S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Wolters Kluwer Health 2021
Pynciau:
ORIGINAL REPORTS
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274807/
https://ncbi.nlm.nih.gov/pubmed/33617303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.20.02759
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