TRANSFORMER: A Randomized Phase II Study Comparing Bipolar Androgen Therapy Versus Enzalutamide in Asymptomatic Men With Castration-Resistant Metastatic Prostate Cancer

PURPOSE: Prostate cancer (PCa) becomes resistant to androgen ablation through adaptive upregulation of the androgen receptor in response to the low-testosterone microenvironment. Bipolar androgen therapy (BAT), defined as rapid cycling between high and low serum testosterone, disrupts this adaptive...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:J Clin Oncol
Autors principals: Denmeade, Samuel R., Wang, Hao, Agarwal, Neeraj, Smith, David C., Schweizer, Michael T., Stein, Mark N., Assikis, Vasileios, Twardowski, Przemyslaw W., Flaig, Thomas W., Szmulewitz, Russell Z., Holzbeierlein, Jeffrey M., Hauke, Ralph J., Sonpavde, Guru, Garcia, Jorge A., Hussain, Arif, Sartor, Oliver, Mao, Shifeng, Cao, Harry, Fu, Wei, Wang, Ting, Abdallah, Rehab, Lim, Su Jin, Bolejack, Vanessa, Paller, Channing J., Carducci, Michael A., Markowski, Mark C., Eisenberger, Mario A., Antonarakis, Emmanuel S.
Format: Artigo
Idioma:Inglês
Publicat: Wolters Kluwer Health 2021
Matèries:
ORIGINAL REPORTS
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274807/
https://ncbi.nlm.nih.gov/pubmed/33617303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.20.02759
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars