TRANSFORMER: A Randomized Phase II Study Comparing Bipolar Androgen Therapy Versus Enzalutamide in Asymptomatic Men With Castration-Resistant Metastatic Prostate Cancer

PURPOSE: Prostate cancer (PCa) becomes resistant to androgen ablation through adaptive upregulation of the androgen receptor in response to the low-testosterone microenvironment. Bipolar androgen therapy (BAT), defined as rapid cycling between high and low serum testosterone, disrupts this adaptive...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Denmeade, Samuel R., Wang, Hao, Agarwal, Neeraj, Smith, David C., Schweizer, Michael T., Stein, Mark N., Assikis, Vasileios, Twardowski, Przemyslaw W., Flaig, Thomas W., Szmulewitz, Russell Z., Holzbeierlein, Jeffrey M., Hauke, Ralph J., Sonpavde, Guru, Garcia, Jorge A., Hussain, Arif, Sartor, Oliver, Mao, Shifeng, Cao, Harry, Fu, Wei, Wang, Ting, Abdallah, Rehab, Lim, Su Jin, Bolejack, Vanessa, Paller, Channing J., Carducci, Michael A., Markowski, Mark C., Eisenberger, Mario A., Antonarakis, Emmanuel S.
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer Health 2021
Assuntos:
ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274807/
https://ncbi.nlm.nih.gov/pubmed/33617303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.20.02759
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