Extreme responses to immune checkpoint blockade following bipolar androgen therapy and enzalutamide in patients with metastatic castration resistant prostate cancer

BACKGROUND: Immune checkpoint inhibition has been shown to have limited efficacy in patients with metastatic prostate cancer. Prostate cancers that harbor certain homologous recombination (HR) DNA repair gene mutations, inactivating CDK12 mutations or have underlying mismatch repair deficiency may b...

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Udgivet i:Prostate
Main Authors: Markowski, Mark C., Shenderov, Eugene, Eisenberger, Mario A., Kachhap, Sushant, Pardoll, Drew M., Denmeade, Samuel R., Antonarakis, Emmanuel S.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7585736/
https://ncbi.nlm.nih.gov/pubmed/31972048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.23955
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