AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer

BACKGROUND: The androgen-receptor isoform encoded by splice variant 7 lacks the ligand-binding domain, which is the target of enzalutamide and abiraterone, but remains constitutively active as a transcription factor. We hypothesized that detection of androgen-receptor splice variant 7 messenger RNA...

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Detalhes bibliográficos
Main Authors: Antonarakis, Emmanuel S., Lu, Changxue, Wang, Hao, Luber, Brandon, Nakazawa, Mary, Roeser, Jeffrey C., Chen, Yan, Mohammad, Tabrez A., Chen, Yidong, Fedor, Helen L., Lotan, Tamara L., Zheng, Qizhi, De Marzo, Angelo M., Isaacs, John T., Isaacs, William B., Nadal, Rosa, Paller, Channing J., Denmeade, Samuel R., Carducci, Michael A., Eisenberger, Mario A., Luo, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201502/
https://ncbi.nlm.nih.gov/pubmed/25184630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1315815
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