AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer

BACKGROUND: The androgen-receptor isoform encoded by splice variant 7 lacks the ligand-binding domain, which is the target of enzalutamide and abiraterone, but remains constitutively active as a transcription factor. We hypothesized that detection of androgen-receptor splice variant 7 messenger RNA...

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Bibliografiske detaljer
Main Authors: Antonarakis, Emmanuel S., Lu, Changxue, Wang, Hao, Luber, Brandon, Nakazawa, Mary, Roeser, Jeffrey C., Chen, Yan, Mohammad, Tabrez A., Chen, Yidong, Fedor, Helen L., Lotan, Tamara L., Zheng, Qizhi, De Marzo, Angelo M., Isaacs, John T., Isaacs, William B., Nadal, Rosa, Paller, Channing J., Denmeade, Samuel R., Carducci, Michael A., Eisenberger, Mario A., Luo, Jun
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201502/
https://ncbi.nlm.nih.gov/pubmed/25184630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1315815
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