AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer

BACKGROUND: The androgen-receptor isoform encoded by splice variant 7 lacks the ligand-binding domain, which is the target of enzalutamide and abiraterone, but remains constitutively active as a transcription factor. We hypothesized that detection of androgen-receptor splice variant 7 messenger RNA...

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Autors principals: Antonarakis, Emmanuel S., Lu, Changxue, Wang, Hao, Luber, Brandon, Nakazawa, Mary, Roeser, Jeffrey C., Chen, Yan, Mohammad, Tabrez A., Chen, Yidong, Fedor, Helen L., Lotan, Tamara L., Zheng, Qizhi, De Marzo, Angelo M., Isaacs, John T., Isaacs, William B., Nadal, Rosa, Paller, Channing J., Denmeade, Samuel R., Carducci, Michael A., Eisenberger, Mario A., Luo, Jun
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201502/
https://ncbi.nlm.nih.gov/pubmed/25184630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1315815
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