Wnt-pathway Activating Mutations Are Associated with Resistance to First-line Abiraterone and Enzalutamide in Castration-resistant Prostate Cancer

BACKGROUND: Wnt signaling is a cellular pathway involved in embryogenesis, development, and neoplasia. Wnt-pathway activation may accelerate prostate cancer androgen-independent growth and mediate antiandrogen resistance. Since 10–20% of advanced prostate cancers harbor Wnt-activating mutations, we...

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Detalhes bibliográficos
Publicado no:Eur Urol
Main Authors: Velho, Pedro Isaacsson, Fu, Wei, Wang, Hao, Mirkheshti, Nooshin, Qazi, Fahad, Lima, Fabiola A.S., Shaukat, Farah, Carducci, Michael A., Denmeade, Samuel R., Paller, Channing J., Markowski, Mark C., Marshall, Catherine H., Eisenberger, Mario A., Antonarakis, Emmanuel S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893106/
https://ncbi.nlm.nih.gov/pubmed/31176623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2019.05.032
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