Genetic Alterations Detected in Cell-Free DNA Are Associated With Enzalutamide and Abiraterone Resistance in Castration-Resistant Prostate Cancer

PURPOSE: Androgen receptor (AR) gene alterations, including ligand-binding domain mutations and copy number (CN) gain, have yet to be fully established as predictive markers of resistance to enzalutamide and abiraterone in men with metastatic castration-resistant prostate cancer (mCRPC). The goal of...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Torquato, Samantha, Pallavajjala, Aparna, Goldstein, Alexa, Valda Toro, Patricia, Silberstein, John L., Lee, Justin, Nakazawa, Mary, Waters, Ian, Chu, David, Shinn, Daniel, Groginski, Taylor, Hughes, Robert M., Simons, Brian W., Khan, Hamda, Feng, Zhaoyong, Carducci, Michael A., Paller, Channing J., Denmeade, Samuel R., Kressel, Bruce, Eisenberger, Mario A., Antonarakis, Emmanuel S., Trock, Bruce J., Park, Ben H., Hurley, Paula J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2019
Assuntos:
Original Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532665/
https://ncbi.nlm.nih.gov/pubmed/31131348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00227
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