Genetic Alterations Detected in Cell-Free DNA Are Associated With Enzalutamide and Abiraterone Resistance in Castration-Resistant Prostate Cancer

PURPOSE: Androgen receptor (AR) gene alterations, including ligand-binding domain mutations and copy number (CN) gain, have yet to be fully established as predictive markers of resistance to enzalutamide and abiraterone in men with metastatic castration-resistant prostate cancer (mCRPC). The goal of...

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Pubblicato in:JCO Precis Oncol
Autori principali: Torquato, Samantha, Pallavajjala, Aparna, Goldstein, Alexa, Valda Toro, Patricia, Silberstein, John L., Lee, Justin, Nakazawa, Mary, Waters, Ian, Chu, David, Shinn, Daniel, Groginski, Taylor, Hughes, Robert M., Simons, Brian W., Khan, Hamda, Feng, Zhaoyong, Carducci, Michael A., Paller, Channing J., Denmeade, Samuel R., Kressel, Bruce, Eisenberger, Mario A., Antonarakis, Emmanuel S., Trock, Bruce J., Park, Ben H., Hurley, Paula J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2019
Soggetti:
Original Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532665/
https://ncbi.nlm.nih.gov/pubmed/31131348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00227
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