Efficacy of Radium-223 in Bone-metastatic Castration-resistant Prostate Cancer with and Without Homologous Repair Gene Defects

BACKGROUND: Pathogenic mutations in genes mediating homologous recombination (HR) DNA repair are present in 20-30% of men with metastatic castrate-resistant prostate cancer (mCRPC). Radium-223 is a bone-seeking α-emitter that induces double-strand DNA breaks, thereby killing cancer cells in the bone...

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Detalhes bibliográficos
Publicado no:Eur Urol
Main Authors: Velho, Pedro Isaacsson, Qazi, Fahad, Hassan, Sayeedul, Carducci, Michael A., Denmeade, Samuel R., Markowski, Mark C., Thorek, Daniel L., DeWeese, Theodore L., Song, Daniel Y., Tran, Phuoc T., Eisenberger, Mario A., Antonarakis, Emmanuel S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447475/
https://ncbi.nlm.nih.gov/pubmed/30293905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2018.09.040
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