Efficacy of Radium-223 in Bone-metastatic Castration-resistant Prostate Cancer with and Without Homologous Repair Gene Defects

BACKGROUND: Pathogenic mutations in genes mediating homologous recombination (HR) DNA repair are present in 20-30% of men with metastatic castrate-resistant prostate cancer (mCRPC). Radium-223 is a bone-seeking α-emitter that induces double-strand DNA breaks, thereby killing cancer cells in the bone...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Eur Urol
Päätekijät: Velho, Pedro Isaacsson, Qazi, Fahad, Hassan, Sayeedul, Carducci, Michael A., Denmeade, Samuel R., Markowski, Mark C., Thorek, Daniel L., DeWeese, Theodore L., Song, Daniel Y., Tran, Phuoc T., Eisenberger, Mario A., Antonarakis, Emmanuel S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447475/
https://ncbi.nlm.nih.gov/pubmed/30293905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2018.09.040
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