Efficacy of Radium-223 in Bone-metastatic Castration-resistant Prostate Cancer with and Without Homologous Repair Gene Defects

BACKGROUND: Pathogenic mutations in genes mediating homologous recombination (HR) DNA repair are present in 20-30% of men with metastatic castrate-resistant prostate cancer (mCRPC). Radium-223 is a bone-seeking α-emitter that induces double-strand DNA breaks, thereby killing cancer cells in the bone...

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Veröffentlicht in:Eur Urol
Hauptverfasser: Velho, Pedro Isaacsson, Qazi, Fahad, Hassan, Sayeedul, Carducci, Michael A., Denmeade, Samuel R., Markowski, Mark C., Thorek, Daniel L., DeWeese, Theodore L., Song, Daniel Y., Tran, Phuoc T., Eisenberger, Mario A., Antonarakis, Emmanuel S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447475/
https://ncbi.nlm.nih.gov/pubmed/30293905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2018.09.040
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